Locationthe st regis florence is 500 m from il duomo and within 1 km 06 mi of the church of santa maria novella the ponte vecchio and the uffizi gallery the statue of david is approximately 1 km 06 mi from the hotel hotel featuresbuilt in the 1400s the st regis florence was originally a palace designed for a family of nobles it became a hotel in the 19th century since then celebrated figures from around the world have visited the st regis florences stained glass ceilings