A hub of history and culture in the south welcome to the hampton inn columbia i 20clemson rd sc take your time to explore the many sides of columbia the souths hub of culture art and history the hampton inn hotel in columbia i 20clemson rd sc is located in northeast columbia just off of i 20 and within minutes of major shopping and attractions see amazing history and architecture at the south carolina statehouse featuring a copper dome and bronze stars marking where general sherma