The shimano tiagra ch 4601 chain is compatible with the new series of shimano directional road chains asymmetrical plates eases theshifting on the most difficult shifts up the cassette in the rear and shifting up from the small ring into the large chainring this chain is designed to shift quickly and quietly on shimano tiagra 4600 105 5700 ultegra 6700 and dura ace 7900 cassetteschainrings shimano 10 speed road compatible compatible with 10 speed tiagra not 9 speed