How does creatine actually work creatine monohydrate is the sports supplement industrys most researched and widely used product sci mxs creatine monohydrate assists the bodys natural production of atp which is the fuel used by the muscles during intense muscle contraction creatine monohydrate increases strength levels in weight training or other forms of strength training which results in additional micro trauma to muscle tissue leading to adaptive muscle growth creatine monohydrate supple