Up to 8 hour relief immediate cooling relief for migraine severe headache ready to use non medicinal kool n soothe migraine are soft gel sheets designed to provide immediate cooling relief to the severe discomfort associated with migraine and headaches kool n soothe migraine is safe to use with pain relief medication for maximum comfort ready to use and with no need for refrigeration each gel sheet stays in place and provides up to 8 hours of cooling relief kool n soothe