Voted the hippest neighborhood in the us san franciscos first neighborhood the mission district is still the heart and soul of vibrant san francisco youve shopped at union square youve eaten crab louis on fishermans wharf and had pot stickers in chinatown youve strolled through north beach and ridden halfway to the stars on a little cable car these are all perfectly pleasant ways to spend time in san francisco but theyre not the end of the story theyre not even the beginning san