Atovaquoneproguanil hydrochloride is the first generic version and is cheaper than branded malarone atovaquoneproguanil hydrochloride contains two active ingredientsatovaquone and progunail hydrochloride atovaquoneproguanil hydrochloride tablets are used in two ways to prevent malaria in adults and children who weigh more than 40kg and to treat malaria in adults and children who weigh more than 11kg malaria is spread by the bite of an infected mosquito which passes the malaria paras